I have been using GTD methodology for a couple of years and a friend told me about OmniFocus. Let’s just say it has helped me manage not only multiple workplace responsibilities, but also home projects, even hobby checklists. And the best thing about it is that it shares all across my devices, Mac, iPad, and iPhone. Instant access. I love that I can forward emails natively to Omnifocus from my email and instantly put them in an inbox to create or add to projects. Once the learning curve is crossed, which is not too substantial, really a manner of learning some vocabulary (like contexts), Omnifocus becomes the intuitive way to start and manage each day.
Mr. Trout Snout about OmniFocus 2